A Pediatric Board Forum by PBR Has MOVED! » Topic: Tetanus titers in agammaglobinemia http://forum.pediatricsboardreview.com/forums/topic/tetanus-titers-in-agammaglobinemia/feed Wed, 08 Apr 2026 17:14:41 +0000 http://bbpress.org/?v=2.5.8-5815 en-US http://forum.pediatricsboardreview.com/forums/topic/tetanus-titers-in-agammaglobinemia/#post-173 <![CDATA[Tetanus titers in agammaglobinemia]]> http://forum.pediatricsboardreview.com/forums/topic/tetanus-titers-in-agammaglobinemia/#post-173 Wed, 03 Oct 2012 00:59:06 +0000 ppat On page 58 of the hard copy-under IMMUNOLOGY TESTS, A RECAP, you write “an ABP fav “when testing for knowledge of agammaglobinemia. I’m confused by that statement? How does that relate to tetanus titers and B cell deficiency?

]]> http://forum.pediatricsboardreview.com/forums/topic/tetanus-titers-in-agammaglobinemia/#post-174 <![CDATA[Reply To: Tetanus titers in agammaglobinemia]]> http://forum.pediatricsboardreview.com/forums/topic/tetanus-titers-in-agammaglobinemia/#post-174 Wed, 03 Oct 2012 01:00:12 +0000 ashish Regarding agammaglobinemia… I was talking about the fact that it’s a B-cell def. So titers for tetanus and diphtheria will be low even after immunization. ABP likes for you to know that fact and can test around that information in many different ways. Here’s the updated section:

 

TITERS

If you suspect a B-cell (aka Humoral) deficiency, test for it by obtaining antiBody TITERS for something the child was already immunized against, such as TETANUS (testing for tetanus titers in patients with Agammaglobulinemia, a B-cell deficiency, is a an ABP favorite way of testing your knowledge). Could also test for titers against Diphtheria and Streptococcus/Pneumococcus. Do not get confused with getting SKIN TESTING for tetanus/Candida/Mumps/PPD which all test for T-cell mediated (aka cellular) immunity.

PEARLS: 

* Infections related to B-cell deficiencies rarely occur before 6 months of age because of presence of maternal antibodies.

* ANTIBODY SUBCLASSES: If IgG levels are in the normal range but you still have a high suspicion for a B-cell/Humoral defect, consider checking for the presence of Ig subclasses for Tetanus, Pneumococcus, etc.

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