Vitamin D 1,25-OH is the ACTIVE form

The Pediatrics Board Review Forum Has MOVED! Forums PEDIATRIC ENDOCRINOLOGY Vitamin D 1,25-OH is the ACTIVE form

This topic contains 1 reply, has 2 voices, and was last updated by  ashish 11 years, 6 months ago.

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  • #255

    kotl
    Participant

    For the second mnemonic under Vitamin D & Its Evaluation, I think it should read “Which one is the ACTIVE form?” instead of ‘inactive’ form. Since the subsequent lines talk about the 1,25-OH Vit D. Right?

    #256

    ashish
    Member

    You are correct and thank you for the catch!

    Here’s the updated version:

    VITAMIN D & ITS EVALUATION

    The liver sends 25-Vitamin D to the kidneys where it gets hydroxylated to 1,25 Vitamin D (the active form). If looking for a nutritional deficiency, obtain a 25-Vitamin D level. SUPPLEMENT with 1,25 Vitamin D (the ACTIVE form). Typically, 25-Vit D is the first one you should check (especially if they ask for a screen).

    MNEMONIC: Where is the Vitamin D produced that carries 2 numbers with it (1 and 25)? TWO organs = TWO kidneys = TWO numbers (1 and 25)!

    MNEMONIC: Which one is the active form? Think of it this way… if you ingest a calcium containing food in its natural form, it will first go to the gut, then the liver, then the blood, then finally the kidneys! So keeping the above mnemonic in mind, it’s the Vitamin D with TWO numbers!

    PEARLS: Here are some ways Vitamin D deficiency could present

    * African-American (AA) breastfed child whose mom is not on Vitamin D supplementation

    * African-American (AA) breastfed child whose mom is not getting enough sunlight

    * Child with symptoms consistent with malabsorption

    * Child with a history of epilepsy who is on anti-seizure medications

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